Article

A structure-guided antibody detects SOD1 oligomers in diverse ALS genotypes

2025-05-08

Abstract excerpt

Antibodies offer versatility as diagnostic and therapeutic tools to target specific protein epitopes. However, the transient nature of intermediate protein conformations, such as that of amyloid oligomers, poses a challenge for antibody development. We use a structure-guided approach to generate a monoclonal antibody against oligomers of Superoxide Dismutase 1 (SOD1). Mutations in SOD1 are linked to a subset of fa...

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Literature Corpus work: 595f7c34-8243-5381-b5d1-e6b593d92064
DOI: 10.1101/2025.05.05.652290

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