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Novel Antibodies Reveal Inclusions Containing Non-Native SOD1 in Sporadic ALS Patients

14 Jul 2010

Abstract excerpt

Mutations in CuZn-superoxide dismutase (SOD1) cause amyotrophic lateral sclerosis (ALS) and are found in 6% of ALS patients. Non-native and aggregation-prone forms of mutant SOD1s are thought to trigger the disease. Two sets of novel antibodies, raised in rabbits and chicken, against peptides spaced along the human SOD1 sequence, were by enzyme-linked immunosorbent assay and an immunocapture method shown to be...

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PMID: 20644736
DOI: 10.1371/journal.pone.0011552

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