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Article

A novel monoclonal antibody reveals a conformational alteration shared by amyotrophic lateral sclerosis-linked SOD1 mutants.

Annals of neurology - 1 Nov 2012

Fujisawa Takao, Homma Kengo, Yamaguchi Namiko, Kadowaki Hisae, Tsuburaya Naomi, Naguro Isao, Matsuzawa Atsushi, Takeda Kohsuke, Takahashi Yuji, Goto Jun, Tsuji Shoji, Nishitoh Hideki, Ichijo Hidenori

Abstract excerpt

OBJECTIVE: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that is characterized by the selective loss of upper and lower motoneurons. Although >100 different Cu, Zn superoxide dismutase (SOD1) mutations have been identified in ALS patients, it remains controversial whether all of them are disease-causative mutations. Therefore, it is necessary to develop molecular mechanism-based...

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Identifiers

PMID: 23280792
DOI: 10.1002/ana.23668

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SOD1

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