Article
Identification of Drug Transporter Genomic Variants and Inhibitors That Protect Against Doxorubicin-Induced Cardiotoxicity.
Circulation - 25 Jan 2022
Magdy Tarek, Jouni Mariam, Kuo Hui-Hsuan, Weddle Carly J, Lyra-Leite Davi, Fonoudi Hananeh, Romero-Tejeda Marisol, Gharib Mennat, Javed Hoor, Fajardo Giovanni, Ross Colin J D, Carleton Bruce C, Bernstein Daniel, Burridge Paul W
Abstract excerpt
BACKGROUND: Multiple pharmacogenomic studies have identified the synonymous genomic variant rs7853758 (G > A, L461L) and the intronic variant rs885004 in SLC28A3 (solute carrier family 28 member 3) as statistically associated with a lower incidence of anthracycline-induced cardiotoxicity. However, the true causal variant(s), the cardioprotective mechanism of this locus, the role of SLC28A3 and other solute...
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