Article

Impact of South African 501.V2 Variant on SARS-CoV-2 Spike Infectivity and Neutralization: A Structure-based Computational Assessment

2021-01-11

Abstract excerpt

<h4>Motivation</h4> The SARS-CoV-2 variants emerging from South Africa (501.V2) and the UK (B.1.1.7) necessitate rapid assessment of the effects of the corresponding amino acid substitutions in the spike (S) receptor-binding domain (RBD) of the variants on the interactions with the human ACE2 receptor and monoclonal antibodies (mAbs) reported earlier to neutralize the spike. <h4>Results</h4> Molecular modeling a...

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Literature Corpus work: 5936620d-2dcd-5b56-b61d-8fd5baf6abc2
DOI: 10.1101/2021.01.10.426143

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