Article
CRISPR/Cas9‑mediated cervical cancer treatment targeting human papillomavirus E6
10 Dec 2018
Abstract excerpt
High‑risk human papillomavirus (HPV) is a common cause of cervical cancer. HPV E6 oncoprotein promotes the degradation of host tumor suppressor gene p53, leading to the development of tumors. Therapeutic strategies that specifically target E6, which is constitutively expressed in tumors and is not present in normal tissues, may be highly effective and safe. CRISPR‑CRISPR associated protein 9 (Cas9) is one of the...