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Article

Comprehensive molecular characterization of human adipocytes reveals a transient brown phenotype.

Journal of translational medicine - 30 Apr 2015

Guennoun Andrea, Kazantzis Melissa, Thomas Remy, Wabitsch Martin, Tews Daniel, Seetharama Sastry Konduru, Abdelkarim Mouaadh, Zilberfarb Vladimir, Strosberg Arthur Donny, Chouchane Lotfi

Abstract excerpt

BACKGROUND: Functional brown adipose tissue (BAT), involved in energy expenditure, has recently been detected in substantial amounts in adults. Formerly overlooked BAT has now become an attractive anti-obesity target. METHODS AND RESULTS: Molecular characterization of human brown and white adipocytes, using a myriad of techniques including high-throughput RNA sequencing and functional assays, showed that PAZ6 and...

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Identifiers

PMID: 25925588
DOI: 10.1186/s12967-015-0480-6
PMCID: PMC4438513

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UCP1

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