Article
The catalytic subunit of the first mannosyltransferase in the GPI biosynthetic pathway affects growth, cell wall integrity and hyphal morphogenesis in Candida albicans.
Yeast (Chichester, England) - 1 Aug 2016
Singh Sneh Lata, Rai Ramesh Chandra, Sah Sudisht Kumar, Komath Sneha Sudha
Abstract excerpt
CaGpi14 is the catalytic subunit of the first mannosyltransferase that is involved in the glycosylphosphatidylinositol (GPI) biosynthetic pathway in Candida albicans. We show that CaGPI14 is able to rescue a conditionally lethal gpi14 mutant of Saccharomyces cerevisiae, unlike its mammalian homologue. The depletion of this enzyme in C. albicans leads to severe growth defects, besides causing deficiencies in GPI...
Topics
- Basic-Leucine Zipper Transcription Factors
- Candida albicans
- Catalytic Domain
- Cell Wall
- Genes, Lethal
- Glycosylphosphatidylinositols
- Hyphae
- Mannosyltransferases
- Mitogen-Activated Protein Kinases
- Morphogenesis
- Mutation
- Osmotic Pressure