Article

Neoantigen DNA vaccines are safe, feasible, and capable of inducing neoantigen-specific immune responses in patients with triple negative breast cancer

2021-11-21

Abstract excerpt

<h4>ABSTRACT</h4> <h4>PURPOSE</h4> Cancer neoantigens are important targets of cancer immunotherapy. Neoantigen vaccines have the potential to induce or enhance highly specific antitumor immune responses with minimal risk of autoimmunity. We have developed a neoantigen DNA vaccine platform capable of efficiently presenting both HLA class I and II epitopes. To test the safety, feasibility and efficacy of this platf...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8f8956c7-f6ec-5e0d-9702-50e2b835728a
DOI: 10.1101/2021.11.19.21266466

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Neoantigen DNA vaccines are safe, feasible, and capable of inducing neoantigen-specific immune responses in patients with triple negative breast cancerDOI 10.1101/2021.11.19.21266466Read

Personalized Neoantigen DNA Cancer Vaccines: Current Status and Future PerspectivesSemantic proximity Read

A Synthetic DNA, Multi-Neoantigen Vaccine Drives Predominately MHC Class I CD8+ T-cell Responses, Impacting Tumor ChallengeSemantic proximity Read

Neoantigens: The Novel Precision Cancer ImmunotherapySemantic proximity Read

Optimized polyepitope neoantigen DNA vaccines elicit neoantigen-specific immune responses in preclinical models and in clinical translationSemantic proximity Read

Neoantigen-based personalized cancer vaccines: the emergence of precision cancer immunotherapySemantic proximity Read

<i>In vitro</i> validation of neoantigen prediction algorithm for developing personalized cancer vaccine therapySemantic proximity Read

Breast Cancer Neoantigens Can Induce CD8+ T-Cell Responses and Antitumor Immunity.Semantic proximity Read

Cancer neoantigens as potential targets for immunotherapy.Semantic proximity Read

Stimulating T cell responses against patient-derived breast cancer cells with neoantigen peptide-loaded peripheral blood mononuclear cellsSemantic proximity Read

Synthetic multiepitope neoantigen DNA vaccine for personalized cancer immunotherapy.Semantic proximity Read

HLA class-I and class-II restricted neoantigen loads predict overall survival in breast cancerSemantic proximity Read

New emerging targets in cancer immunotherapy: the role of neoantigensSemantic proximity Read