Article

Is tumor mutational burden predictive of response to immunotherapy?

2020-09-04

Abstract excerpt

Cancer immunotherapy by checkpoint blockade (ICB) is effective for various cancer types, yet its clinical use is encumbered by a high variability of patient response. Several studies have reported that the number of non-synonymous mutations (Tumor Mutational Burden, TMB), can predict patient response to ICB. This belief has become widespread and led to the FDA approval of immunotherapy patient prioritization based...

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Literature Corpus work: 8b0243a8-7284-5107-b3f1-39e6795129e5
DOI: 10.1101/2020.09.03.260265

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