Article
Chemotherapy weakly contributes to predicted neoantigen expression in ovarian cancer.
BMC cancer - 22 Jan 2018
O'Donnell Timothy, Christie Elizabeth L, Ahuja Arun, Buros Jacqueline, Aksoy B Arman, Bowtell David D L, Snyder Alexandra, Hammerbacher Jeff
Abstract excerpt
BACKGROUND: Patients with highly mutated tumors, such as melanoma or smoking-related lung cancer, have higher rates of response to immune checkpoint blockade therapy, perhaps due to increased neoantigen expression. Many chemotherapies including platinum compounds are known to be mutagenic, but the impact of standard treatment protocols on mutational burden and resulting neoantigen expression in most human cancers...
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