Article

GnRH pulse generator activity in mouse models of polycystic ovary syndrome

2024-06-06

Abstract excerpt

One in ten women in their reproductive age suffer from polycystic ovary syndrome (PCOS) that, alongside subfertility and hyperandrogenism, typically presents with increased luteinizing hormone (LH) pulsatility. As such, it is suspected that the arcuate kisspeptin (ARN KISS ) neurons that represent the GnRH pulse generator are dysfunctional in PCOS. We used here in vivo GCaMP fiber photometry and other approaches...

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Literature Corpus work: 589e0df7-cfa5-51ed-ad34-fe041e029835
DOI: 10.1101/2024.06.04.597387

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