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Article

Pulsatile and sustained gonadotropin-releasing hormone (GnRH) receptor signaling: does the ERK signaling pathway decode GnRH pulse frequency?

The Journal of biological chemistry - 6 Aug 2010

Armstrong Stephen P, Caunt Christopher J, Fowkes Robert C, Tsaneva-Atanasova Krasimira, McArdle Craig A

Abstract excerpt

Gonadotropin-releasing hormone (GnRH) acts via G-protein-coupled receptors on gonadotrophs to stimulate synthesis and secretion of luteinizing hormone and follicle-stimulating hormone. It is secreted in pulses, and its effects depend on pulse frequency, but decoding mechanisms are unknown. Here we have used an extracellular signal regulated kinase-green fluorescent protein (ERK2-GFP) reporter to monitor GnRH...

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Source

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Identifiers

PMID: 20507982
DOI: 10.1074/jbc.M110.115964
PMCID: PMC2915671

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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