Untargeted Metabolomics Unveils Metabolic Biomarkers in HFpEF

Abstract excerpt

<title>Abstract</title> <p>Background Heart failure with preserved ejection fraction (HFpEF) is a complex condition linked to metabolic disturbances. This study aimed to identify plasma metabolic signatures in HFpEF patients using untargeted metabolomic profiling. Methods We analyzed data from 30 HFpEF patients and 30 matched healthy controls. Untargeted metabolomic profiling via UHPLC-MS/MS was conducted on veno...

Topics

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• Energy Metabolism
• Heart Failure
• Mendelian Randomization Analysis
• Metabolomics
• Multiomics
• Myocytes, Cardiac
• Single-Cell Analysis
• Single-Cell Gene Expression Analysis

Identifiers and source

Literature Corpus work

58627143-9c38-5570-8149-b85841b1f862

DOI

10.21203/rs.3.rs-7082748/v1