Broadcasters, receivers, functional groups of metabolites and the link to heart failure progression using polygenic factors

Abstract excerpt

<title>Abstract</title> <p>In a prospective study with records of heart failure (HF) incidence, we present metabolite profiling data from individuals without HF at baseline. We uncovered the interconnectivity of metabolites using data-driven and causal networks augmented with polygenic factors. Exploring the networks, we identified metabolite broadcasters, receivers<bold>,</bold> mediators, and subnetworks corres...

Topics

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• Energy Metabolism
• Heart Failure
• Mendelian Randomization Analysis
• Metabolomics
• Multiomics
• Myocytes, Cardiac
• Single-Cell Analysis
• Single-Cell Gene Expression Analysis

Identifiers and source

Literature Corpus work

19a3cee9-0d19-5b6a-adcd-0242818542c4

DOI

10.21203/rs.3.rs-3246406/v1