Article

HPV16 neutralizing monoclonal antibodies show evidence for common developmental pathways and public epitopes

2025-04-07

Abstract excerpt

Antibodies to human papillomavirus (HPV) primarily recognize surface exposed residues on five loops of the major capsid protein (L1) that vary significantly among HPV types. We determined which loops were required for neutralization for 70 HPV16 specific human monoclonal antibodies (mAbs) cloned from participants who received an HPV vaccine, and we describe molecular features of those antibodies. Chimeric HPV16 ps...

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Literature Corpus work: 584c5d54-9c25-55a8-be98-2ff188324063
DOI: 10.1101/2025.03.31.646278

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