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Article

A human monoclonal antibody against HPV16 recognizes an immunodominant and neutralizing epitope partially overlapping with that of H16.V5.

Scientific reports - 11 Jan 2016

Xia Lin, Xian Yangfei, Wang Daning, Chen Yuanzhi, Huang Xiaofen, Bi Xingjian, Yu Hai, Fu Zheng, Liu Xinlin, Li Shaowei, An Zhiqiang, Luo Wenxin, Zhao Qinjian, Xia Ningshao

Abstract excerpt

The presence of neutralizing epitopes in human papillomavirus (HPV) L1 virus-like particles (VLPs) is the structural basis of prophylactic vaccines. An anti-HPV16 neutralizing monoclonal antibody (N-mAb) 26D1 was isolated from a memory B cell of a human vaccinee. The pre-binding of heparan sulfate to VLPs inhibited the binding of both N-mAbs to the antigen, indicating that the epitopes are critical for viral cell...

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Identifiers

PMID: 26750243
DOI: 10.1038/srep19042
PMCID: PMC4707464

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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