Article

L2 epitope presenting virus-like particles as broad- spectrum vaccine candidates targeting genus beta human papillomaviruses

2025-11-23

Abstract excerpt

<title>Abstract</title> <p>Licensed human papillomavirus (HPV) vaccines do not target cutaneous ßHPV types implicated in skin cancer development in immunosuppressed individuals. The conserved N-terminus of minor capsid protein L2 contains cross-neutralization epitopes, offering the opportunity to develop broad-spectrum vaccine candidates. A sequential immunization strategy using N-terminal L2 fragments of five ßH...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 65d1b823-633d-52c7-a035-9ed30edbe3fc
DOI: 10.21203/rs.3.rs-7903159/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

L2 epitope presenting virus-like particles as broad- spectrum vaccine candidates targeting genus beta human papillomavirusesDOI 10.21203/rs.3.rs-7903159/v1Read

Progress in L2-Based Prophylactic Vaccine Development for Protection against Diverse Human Papillomavirus Genotypes and Associated DiseasesSemantic proximity Read

Chimeric L2-Based Virus-Like Particle (VLP) Vaccines Targeting Cutaneous Human Papillomaviruses (HPV)Semantic proximity Read

VLPs Displaying a Single L2 Epitope Induce Broadly Cross-Neutralizing Antibodies against Human PapillomavirusSemantic proximity Read

A Pan-HPV Vaccine Based on Bacteriophage PP7 VLPs Displaying Broadly Cross-Neutralizing Epitopes from the HPV Minor Capsid Protein, L2Semantic proximity Read

Virus-like Particle-Based L2 Vaccines against HPVs: Where Are We Today?Semantic proximity Read

RG1-VLP and Other L2-Based, Broad-Spectrum HPV Vaccine CandidatesSemantic proximity Read

Broad Cross-Protection Is Induced in Preclinical Models by a Human Papillomavirus Vaccine Composed of L1/L2 Chimeric Virus-Like ParticlesSemantic proximity Read

RG2-VLP: a Vaccine Designed to Broadly Protect against Anogenital and Skin Human Papillomaviruses Causing Human CancerSemantic proximity Read

Protection against heterologous human papillomavirus challenge by a synthetic lipopeptide vaccine containing a broadly cross-neutralizing epitope of L2Semantic proximity Read

Identification of Broad-Genotype HPV L2 Neutralization Site for Pan-HPV Vaccine Development by a Cross-Neutralizing Antibody.Semantic proximity Read

In silico/In vivo analysis of high-risk papillomavirus L1 and L2 conserved sequences for development of cross-subtype prophylactic vaccineSemantic proximity Read

Substitution of Human Papillomavirus Type 16 L2 Neutralizing Epitopes Into L1 Surface Loops: The Effect on Virus-Like Particle Assembly and ImmunogenicitySemantic proximity Read