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Structural comparison of four different antibodies interacting with human papillomavirus 16 and mechanisms of neutralization

21 May 2015

Abstract excerpt

Cryo-electron microscopy (cryo-EM) was used to solve the structures of human papillomavirus type 16 (HPV16) complexed with fragments of antibody (Fab) from three different neutralizing monoclonals (mAbs): H16.1A, H16.14J, and H263.A2. The structure-function analysis revealed predominantly monovalent binding of each Fab with capsid interactions that involved multiple loops from symmetry related copies of the major...

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PMID: 25996608
DOI: 10.1016/j.virol.2015.04.016

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