Article

Exaptation of inactivated host enzymes for structural roles in orthopoxviruses and novel protein folds revealed by protein structure modeling

2022-11-22

Abstract excerpt

Viruses with large double-stranded DNA genomes appear to have captured the majority of their genes from the hosts at different stages of evolution. The origin of many virus genes is readily detected through highly significant sequence similarity with cellular homologs. This is the case, in particular, for virus enzymes, such as DNA and RNA polymerases or nucleotide kinases, that retain their catalytic activity aft...

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Literature Corpus work: 5836c5a7-e98a-5e66-8756-f673cae4b72f
DOI: 10.1101/2022.11.22.517515

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