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Extensive ITR expansion of the 2022 Mpox virus genome through gene duplication and gene loss.

Virus genes - 1 Aug 2023

Brinkmann Annika, Kohl Claudia, Pape Katharina, Bourquain Daniel, Thürmer Andrea, Michel Janine, Schaade Lars, Nitsche Andreas

Abstract excerpt

Poxviruses are known to evolve slower than RNA viruses with only 1-2 mutations/genome/year. Rather than single mutations, rearrangements such as gene gain and loss, which have been discussed as a possible driver for host adaption, were described in poxviruses. In 2022 and 2023 the world is being challenged by the largest global outbreak so far of Mpox virus, and the virus seems to have established itself in the...

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Identifiers

PMID: 37256469
DOI: 10.1007/s11262-023-02002-1
PMCID: PMC10230479

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