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Structural and functional insights into the helicase protein E5 of Mpox virus

25 Jun 2024

Abstract excerpt

Mpox virus (MPXV) can cause mpox in humans. Due to its quick and wide spread in the past two years, mpox has turned into a significant public health concern. Helicase E5 is a multi-domain protein; its primer synthesis and DNA unwinding activity are required for genome uncoating and DNA replication of MPXV. However, the in vitro DNA unwinding activity has never been demonstrated. Here, we report the structural and...

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PMID: 38914567
DOI: 10.1038/s41421-024-00680-1

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