Article

D-cysteine inhibits iron-sulfur cluster assembly and impairs tumour growth

2023-10-09

Abstract excerpt

<title>Abstract</title> <p>Selective targeting of cancer cells is a major challenge for cancer therapy. Many cancer cells overexpress the cystine/glutamate antiporter xCT/CD98 to increase the import of L-cystine for antioxidant defense, thus supporting tumour cell survival and progression<sup><sub>1,2</sub></sup>. We have exploited this feature of cancer cells by transforming xCT/CD98 overexpression into a select...

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Literature Corpus work: 581d6386-b0d8-54a3-8d80-826b739e4072
DOI: 10.21203/rs.3.rs-3355970/v1

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