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Targeting spike glycans to inhibit SARS-CoV2 viral entry

11 Sept 2023

Abstract excerpt

SARS-CoV-2 spike harbors glycans which function as ligands for lectins. Therefore, it should be possible to exploit lectins to target SARS-CoV-2 and inhibit cellular entry by binding glycans on the spike protein. Burkholderia oklahomensis agglutinin (BOA) is an antiviral lectin that interacts with viral glycoproteins via N-linked high mannose glycans. Here, we show that BOA binds to the spike protein and is a...

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PMID: 37695910
DOI: 10.1073/pnas.2301518120

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