Article

Protective effects of nicotinamide in a mouse model of glaucoma DBA/2 studied by second-harmonic generation microscopy

2024-03-10

Abstract excerpt

Glaucoma is a blinding disease where the retinal ganglion cells and their axons degenerate. Degradation of axonal microtubules is thought to play a critical role in the pathogenesis, but the mechanism is unknown. Here we investigate whether microtubule disruption in glaucoma can be alleviated by metabolic rescue. The morphology and integrity of microtubules of the retinal nerve fibers were evaluated by second-harm...

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Literature Corpus work: 579ce2df-f0c2-5cae-a7e1-e2f3b5d08551
DOI: 10.1101/2024.03.07.583928

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