Article

Gentamicin B1 is not a minor gentamicin component with major nonsense mutation suppression activity

2018-11-23

Abstract excerpt

Nonsense mutations are single base substitutions that introduce a premature termination codon (PTC) preventing the formation of full-length protein. They are the causative mutations in about 10% of patients in a large number of rare genetic diseases. High concentrations of the antibiotic gentamicin can induce the incorporation of an amino acid at a PTC and formation of full-length protein, a process called PTC rea...

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Literature Corpus work: 576e07ec-b6cb-548f-b64f-1cc84aa61de5
DOI: 10.1101/476564

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