Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Gentamicin B1 is a minor gentamicin component with major nonsense mutation suppression activity.

Proceedings of the National Academy of Sciences of the United States of America - 28 Mar 2017

Baradaran-Heravi Alireza, Niesser Jürgen, Balgi Aruna D, Choi Kunho, Zimmerman Carla, South Andrew P, Anderson Hilary J, Strynadka Natalie C, Bally Marcel B, Roberge Michel

Abstract excerpt

Nonsense mutations underlie about 10% of rare genetic disease cases. They introduce a premature termination codon (PTC) and prevent the formation of full-length protein. Pharmaceutical gentamicin, a mixture of several related aminoglycosides, is a frequently used antibiotic in humans that can induce PTC readthrough and suppress nonsense mutations at high concentrations. However, testing of gentamicin in clinical...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aminopeptidases
Share to Codon, Nonsense

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dipeptidyl-Peptidases and Tripeptidyl-Peptidases

Share to Dystrophin

Share to Gentamicins

Share to Serine Proteases

Share to Tripeptidyl-Peptidase 1

Share to Tumor Suppressor Protein p53

Source

Open in PubMed Open full text

Identifiers

PMID: 28289221
DOI: 10.1073/pnas.1620982114
PMCID: PMC5380045

Genes

DMD
SMARCAL1
TPP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Gentamicin B1 is a minor gentamicin component with major nonsense mutation suppression activity.PMID 28289221Read ↗

Gentamicin B1 is not a minor gentamicin component with major nonsense mutation suppression activitySemantic proximity Read ↗

The minor gentamicin complex component, X2, is a potent premature stop codon readthrough molecule with therapeutic potentialSemantic proximity Read ↗

Small molecule Y-320 stimulates ribosome biogenesis, protein synthesis, and aminoglycoside-induced premature termination codon readthrough.Semantic proximity Read ↗

Development of Novel Aminoglycoside (NB54) with Reduced Toxicity and Enhanced Suppression of Disease-Causing Premature Stop MutationsSemantic proximity Read ↗

Characterization of new-generation aminoglycoside promoting premature termination codon readthrough in cancer cells.Semantic proximity Read ↗

Effects of gentamicin inducing readthrough premature stop Codons: A study of alpha-L-iduronidase nonsense variants in COS-7 Cells.Semantic proximity Read ↗

Novel small molecules potentiate premature termination codon readthrough by aminoglycosides.Semantic proximity Read ↗

PTC124 targets genetic disorders caused by nonsense mutations.Semantic proximity Read ↗

Read-through strategies for suppression of nonsense mutations in Duchenne/ Becker muscular dystrophy: aminoglycosides and ataluren (PTC124).Semantic proximity Read ↗

Genome-scale quantification and prediction of pathogenic stop codon readthrough by small moleculesSemantic proximity Read ↗

[Allele-specific therapy: suppression of nonsense mutations by readthrough inducers].Semantic proximity Read ↗

Clinically relevant aminoglycosides can suppress disease-associated premature stop mutations in the IDUA and P53 cDNAs in a mammalian translation system.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.