Back to search

Article

Elevated urea levels in human frontotemporal dementia and amyotrophic lateral sclerosis <i>post-mortem</i> brain tissue: Evidence of a multi-dementia pathogenic mechanism

2025-11-04

Abstract excerpt

1 Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) represent two neurodegenerative diseases on opposite sides of a movement disorder continuum. However, like many other neurodegenerative diseases, the molecular pathogenesis of FTD and ALS is not fully understood. Our group has previously reported evidence for a pervasive elevation of brain urea levels in five other dementia-causing diseases. H...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
5754dbd8-af3d-5ffa-afe2-f6bde4535a97
DOI
10.1101/2025.11.03.686199
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Elevated urea levels in human frontotemporal dementia and amyotrophic lateral sclerosis <i>post-mortem</i> brain tissue: Evidence of a multi-dementia pathogenic mechanismDOI 10.1101/2025.11.03.686199
Severe and regionally-widespread increases in tissue urea in the human brain represent a novel finding of pathogenic potential in Parkinson’s disease dementiaSemantic proximity
Extensive multiregional urea elevations in vascular dementia point towards a novel shared mechanism of disease amongst the age-related dementiasSemantic proximity
The Need for Biomarkers in the ALS–FTD Spectrum: A Clinical Point of View on the Role of ProteomicsSemantic proximity
Biomarker discovery and development for frontotemporal dementia and amyotrophic lateral sclerosisSemantic proximity
Fluid biomarkers in frontotemporal dementia: past, present and futureSemantic proximity
A(a)LS: Ammonia-induced amyotrophic lateral sclerosisSemantic proximity
A(a)LS: Ammonia-induced amyotrophic lateral sclerosisSemantic proximity
The urinary proteome of individuals with a family history of frontotemporal dementia (FTD) but without known mutations differs from that of healthy controlsSemantic proximity
Proteomic studies in the discovery of cerebrospinal fluid biomarkers for amyotrophic lateral sclerosisSemantic proximity
Metabolomic changes associated with frontotemporal lobar degeneration syndromesSemantic proximity
Distribution of ubiquilin 2 and TDP-43 aggregates throughout the CNS in <i>UBQLN2</i> p.T487I-linked amyotrophic lateral sclerosis and frontotemporal dementiaSemantic proximity
Longitudinal Metabolomic Profiling of Biogenic Amines in Plasma and CSF, and Their Correlation, Reveals Sex-Specific and Age Changes in TgF344 Alzheimer’s Disease Transgenic and Wildtype RatsSemantic proximity
Select a neighboring publication to make it the new centre.