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Article

Genetic Determinants of Creatine Bioavailability and Responsiveness: Emphasis on Common Low-Impact Variants.

Lifestyle genomics - 1 Jan 2026

Ostojic Sergej M, Kavecan Ivana

Abstract excerpt

BACKGROUND: Creatine is a central regulator of cellular energy homeostasis and one of the most extensively studied dietary supplements in human nutrition. Although creatine supplementation consistently increases tissue creatine availability and supports performance and health across diverse populations, substantial interindividual variability in responsiveness persists. Approximately one-quarter of individuals...

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Biological Availability
Creatine
Dietary Supplements
Energy Metabolism
Genetic Variation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Nerve Tissue Proteins

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Open in PubMed Open full text

Identifiers

PMID: 41719210
DOI: 10.1159/000551090
PMCID: PMC13065303

Genes

GAMT
GATM
SLC6A8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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