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DNA methylation landscapes of matched primary and recurrent high grade serous ovarian cancers are preserved throughout disease progression and chemoresistance

2020-08-26

Abstract excerpt

<h4>ABSTRACT</h4> Little is known about the role of global DNA methylation in recurrence and chemoresistance of high grade serous ovarian cancer (HGSOC). We performed whole genome bisulfite sequencing (WGBS) and whole transcriptome sequencing (RNA-seq) to establish methylation and gene expression signatures in 62 primary and recurrent tumors from 28 patients diagnosed with stage III/IV HGSOC. Eleven of these pati...

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Literature Corpus work
56ff367e-47de-5fe6-a1f1-12b42eb042f5
DOI
10.1101/2020.08.25.267161
Open publication

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DNA methylation landscapes of matched primary and recurrent high grade serous ovarian cancers are preserved throughout disease progression and chemoresistanceDOI 10.1101/2020.08.25.267161
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