Article

ORN: Extracting Latent Pathway Activities in Cancer with OR-gate Network

2020-06-08

Abstract excerpt

<h4>ABSTRACT</h4> Pathway level understanding of cancer plays a key role in precision oncology. In this study, we developed a novel data-driven model, called the OR-gate Network (ORN), to simultaneously infer functional relationships among mutations, patient-specific pathway activities, and gene co-expression. In principle, logical OR gates agree with mutual exclusivity patterns in somatic mutations and bicluster...

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Literature Corpus work: 56d61e63-90fb-59f8-aa19-4fe8fc45cb51
DOI: 10.1101/2020.06.07.137992

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