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Article

LMNA-related cardiomyopathy: From molecular pathology to cardiac gene therapy

18 Jan 2025

Abstract excerpt

• A critical analysis of the existing LMNA-related cardiomyopathy disease models highlighting their discrepancy from human patients. • A comprehensive summary of the diverse disease mechanisms emphasizing the difficulty to develop small-molecule drugs to target all the mechanisms. • A review of the potential gene therapy strategies that could overcome the current obstacles in targeted therapy for LMNA-related...

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Identifiers

PMID: 39827909
DOI: 10.1016/j.jare.2025.01.001

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