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BEST4 + cells in the intestinal epithelium

1 Apr 2024

Abstract excerpt

BEST4 + cells are a novel subtype of mature absorptive cells in the human intestinal epithelium highlighted by single-cell transcriptomics. The gene expression profile of BEST4 + cells suggests their role in pH regulation, electrolyte secretion, mucus hydration, and innate immune defense. The absence of BEST4 + cells in mice requires the use of alternative animal models or organoids to decipher the role of this...

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PMID: 38557358
DOI: 10.1152/ajpcell.00042.2024

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