Back to search

Article

Revealing the impact of <i>Pseudomonas aeruginosa</i> quorum sensing molecule 2’-aminoacetophenone on human bronchial-airway epithelium and pulmonary endothelium using a human airway-on-a-chip

2025-03-24

Abstract excerpt

Pseudomonas aeruginosa (PA) causes severe respiratory infections utilizing multiple virulence functions. Our previous findings on PA quorum sensing (QS)-regulated small molecule, 2’-aminoacetophenone (2-AA), secreted by the bacteria in infected tissues, revealed its effect on immune and metabolic functions favouring a long-term presence of PA in the host. However, studies on 2-AA’s specific effects on bronchial-...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
56b3426d-ddb3-5b0e-8242-f499af3f0ab6
DOI
10.1101/2025.03.21.644589
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Revealing the impact of <i>Pseudomonas aeruginosa</i> quorum sensing molecule 2’-aminoacetophenone on human bronchial-airway epithelium and pulmonary endothelium using a human airway-on-a-chipDOI 10.1101/2025.03.21.644589
Evaluating Bacterial Pathogenesis Using a Model of Human Airway Organoids Infected with Pseudomonas aeruginosa BiofilmsSemantic proximity
Molecular exploration of host-pathogen interactions in severe <i>Pseudomonas aeruginosa</i> infection through a multi-level data integration approachSemantic proximity
Stable and assayable polymicrobial human airway model reveals complex interactions between <i>Pseudomonas aeruginosa</i> and lung commensalsSemantic proximity
Human Pleural Fluid and Human Serum Albumin Modulate the Behavior of a Hypervirulent and Multidrug-Resistant (Mdr) <em>Acinetobacter baumannii</em> Representative StrainSemantic proximity
An integrated multi-omics analysis of identifies distinct molecular characteristics in pulmonary infections of Pseudomonas aeruginosaSemantic proximity
Establishment and characterization of persistent Pseudomonas aeruginosa infections in air–liquid interface cultures of human airway epithelial cellsSemantic proximity
Network analysis for identifying potential anti-virulence targets through whole transcriptome analysis of <i>Pseudomonas aeruginosa</i> and <i>Staphylococcus aureus</i> exposed to certain anti-pathogenic polyherbal formulationsSemantic proximity
Airway Epithelial Cell Integrity Protects from Cytotoxicity of <i>Pseudomonas aeruginosa</i> Quorum-Sensing SignalsSemantic proximity
Pyocyanin disrupts airway regeneration to favor chronic <i>Pseudomonas aeruginosa</i> infectionSemantic proximity
Microbial Signaling Networks: Bridging Cellular Communication with Applications in Health, Agriculture, and BiotechnologySemantic proximity
Quorum sensing inhibitors: a patent review (2014–2018)Semantic proximity
E.PathDash, pathway activation analysis of publicly available pathogen gene expression dataSemantic proximity
Select a neighboring publication to make it the new centre.