Establishment and characterization of persistent Pseudomonas aeruginosa infections in air–liquid interface cultures of human airway epithelial cells

Abstract excerpt

ABSTRACT Bacteria exhibit distinct behaviors in laboratory settings compared to infection environments. The presence of host cells induces changes in bacterial activity, while pathogens trigger immune responses that shape the microenvironment. Studying infection dynamics by microscopy, cytokine screening, and dual RNA sequencing in an air–liquid interface model, we found that prolonged Pseudomonas aeruginosa...

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