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Mitophagy in Alzheimer’s Disease and Other Age-Related Neurodegenerative Diseases

8 Jan 2020

Abstract excerpt

Mitochondrial dysfunction is a central aspect of aging and neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and Huntington's disease. Mitochondria are the main cellular energy powerhouses, supplying most of ATP by oxidative phosphorylation, which is required to fuel essential neuronal functions. Efficient removal of aged and dysfunctional mitochondria...

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PMID: 31936292
DOI: 10.3390/cells9010150

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