Article

METTL17 is an Fe-S cluster checkpoint for mitochondrial translation

2022-11-24

Abstract excerpt

<h4> A bstract </h4> Friedreich’s ataxia (FA) is the most common monogenic mitochondrial disease. FA is caused by a depletion of the mitochondrial protein frataxin (FXN), an iron-sulfur (Fe-S) cluster biogenesis factor. To better understand the cellular consequences of FA, we performed quantitative proteome profiling of human cells depleted for FXN. Nearly every known Fe-S cluster-containing protein was deplete...

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Literature Corpus work: 5699e6ad-b7f8-5320-8e28-9b348cdb88cc
DOI: 10.1101/2022.11.24.517765

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