Article

Inhibition of HIF-1α accumulation in prostate cancer cells is initiated during early stages of mammalian orthoreovirus infection

2020-09-02

Abstract excerpt

<h4>ABSTRACT</h4> Mammalian orthoreovirus (MRV) is a safe and effective cancer killing virus that has completed Phase I-III clinical trials against numerous cancer types. While many patients experience benefit from MRV therapy, pre-defined set points necessary for FDA approval have not been reached. Therefore, additional research into MRV biology and the effect of viral therapy on different tumor genetic subtypes...

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Literature Corpus work: 565d1168-2434-5498-957f-8b60c1b9eb6c
DOI: 10.1101/2020.09.02.279810

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