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Co-Targeting Nuclear Export and Translation Initiation Uncovers a Therapeutic Vulnerability in Lethal Prostate Cancer

2026-05-07

Abstract excerpt

<h4>ABSTRACT</h4> Metastatic castration-resistant prostate cancer (mCRPC) remains lethal as adaptive resistance to standard-of-care therapy develops, often driven by AR splice variants alongside transcriptional and translational reprogramming. To identify strategies capable of overcoming these mechanisms, we performed an unbiased high-throughput screen of 2,480 mechanistically annotated compounds across advanced...

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Literature Corpus work
0d24412b-82a0-545f-a068-4a81f3e8a361
DOI
10.64898/2026.05.04.722693
Open publication

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Co-Targeting Nuclear Export and Translation Initiation Uncovers a Therapeutic Vulnerability in Lethal Prostate CancerDOI 10.64898/2026.05.04.722693
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