Stratified computational meta-analysis of 2213 acute myeloid leukemia patients reveals age- and sex-dependent gene expression signatures

Abstract excerpt

In 2018 alone, an estimated 20,000 new acute myeloid leukemia (AML) patients were diagnosed, in the United States, and over 10,000 of them are expected to die from the disease. AML is primarily diagnosed among the elderly (median 68 years old at diagnosis). Prognoses have significantly improved for younger patients, but in patients older than 60 years old as much as 70% of patients will die within a year of diagno...

Topics

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• Acute Myeloid Leukemia Research
• Age Factors
• Aged
• Aging
• Leukemia, Myeloid, Acute
• Mutation
• Myelodysplastic Syndromes
• Prognosis

Identifiers and source

Literature Corpus work

5615bd4b-2734-5e78-84c3-176f1fc27aa0

DOI

10.1101/494948