Article

DNMT mRNA stability and YB-1 cooperatively regulate ABCB1 to drive cisplatin chemoresistance in cholangiocarcinoma

2026-06-07

Abstract excerpt

<h4>Background and Aims</h4> Intrahepatic cholangiocarcinoma (iCCA) is a tumor type with a high lethality due to late diagnosis and profound resistance to conventional chemotherapy. To date the molecular mechanisms underlying multidrug resistance remain poorly defined. Here, we integrate single-cell transcriptomics, clinicopathological analysis, and functional genomics to elucidate the molecular basis of cisplati...

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Literature Corpus work: 56024e98-c0d3-5af3-842b-eb91092a1c42
DOI: 10.64898/2026.06.05.730343

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