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Article

The Notch signaling pathway in skeletal muscle health and disease

15 Aug 2022

Abstract excerpt

The Notch signaling pathway is a key regulator of skeletal muscle development and regeneration. Over the past decade, the discoveries of three new muscle disease genes have added a new dimension to the relationship between the Notch signaling pathway and skeletal muscle: MEGF10, POGLUT1, and JAG2. We review the clinical syndromes associated with pathogenic variants in each of these genes, known molecular and...

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PMID: 35968817
DOI: 10.1002/mus.27684

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