Chemical stimuli override a temperature-dependent morphological program by reprogramming the transcriptome of a fungal pathogen

Abstract excerpt

The human fungal pathogen Histoplasma changes its morphology in response to temperature. At 37°C it grows as a budding yeast whereas at room temperature it transitions to hyphal growth. Prior work has demonstrated that 15-20% of transcripts are temperature-regulated, and that transcription factors Ryp1-4 are necessary to establish yeast growth. However, little is known about transcriptional regulators of the hyph...

Topics

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• Antifungal resistance and susceptibility
• Fungal and yeast genetics research
• Fungal Infections and Studies
• Phytoplasmas and Hemiptera pathogens
• Plant-Microbe Interactions and Immunity
• RNA and protein synthesis mechanisms
• Yeasts and Rust Fungi Studies

Identifiers and source

Literature Corpus work

55c1aa1d-c98c-5ff9-acda-0f82c66da00b

DOI

10.1101/2023.04.21.537729