Conserved factors Ryp2 and Ryp3 control cell morphology and infectious spore formation in the fungal pathogen <i>Histoplasma capsulatum</i>

Abstract excerpt

The human fungal pathogen Histoplasma capsulatum grows in a sporulating filamentous form in the soil and, after inhalation of infectious spores, converts to a pathogenic yeast form inside host macrophages in response to temperature. Here we report the identification of two genes (RYP2 and RYP3) required for yeast-phase growth. Ryp2 and Ryp3 are homologous to each other and to the Velvet A family of regulatory...