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A Temperature-Responsive Network Links Cell Shape and Virulence Traits in a Primary Fungal Pathogen

23 Jul 2013

Abstract excerpt

Survival at host temperature is a critical trait for pathogenic microbes of humans. Thermally dimorphic fungal pathogens, including Histoplasma capsulatum, are soil fungi that undergo dramatic changes in cell shape and virulence gene expression in response to host temperature. How these organisms link changes in temperature to both morphologic development and expression of virulence traits is unknown. Here we...

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PMID: 23935449
DOI: 10.1371/journal.pbio.1001614

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