Article

Early Treatment with Integrase Inhibitor Achieves a Functional Cure for Pediatric SIV Infection

2021-04-16

Abstract excerpt

<title>Abstract</title> <p>Neonatal HIV infection causes rapid disease progression to end-stage of AIDS if untreated. To date, there are no reported cases of a genuine functional cure in Pediatric AIDS ClinicalTrial Group lacking integrase inhibitor regimen, even when initiated early. In this study, three infant rhesus macaques born on the same day were intravenously infected with SIV on the day of birth and rece...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 55af1b89-6096-5d22-bd75-b15e3c4ddb4e
DOI: 10.21203/rs.3.rs-426657/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Early Treatment with Integrase Inhibitor Achieves a Functional Cure for Pediatric SIV InfectionDOI 10.21203/rs.3.rs-426657/v1Read

Early Treatment Regimens Achieve Sustained Virologic Remission in Infant Macaques Infected with SIV at BirthSemantic proximity Read

Immunology of pediatric HIV infectionSemantic proximity Read

Simian Immunodeficiency Virus Persistence in Cellular and Anatomic Reservoirs in Antiretroviral Therapy-Suppressed Infant Rhesus MacaquesSemantic proximity Read

Simian-Human Immunodeficiency Virus SHIV.C.CH505 Persistence in ART-Suppressed Infant Macaques Is Characterized by Elevated SHIV RNA in the Gut and a High Abundance of Intact SHIV DNA in Naive CD4 + T CellsSemantic proximity Read

Assessing the impact of autologous neutralizing antibodies on viral rebound in postnatally SHIV-infected ART-treated infant rhesus macaquesSemantic proximity Read

A trial of three antiretroviral regimens in HIV-1-infected children.Semantic proximity Read

A novel HIV triple broadly neutralizing antibody (bNAb) combination-based passive immunization of infant rhesus macaques achieves durable protective plasma neutralization levels and mediates anti-viral effector functionsSemantic proximity Read

Slow progression of pediatric HIV associates with early CD8+ T cell PD-1 expression and a stem-like phenotype.Semantic proximity Read

Paediatric antiretroviral therapy challenges with emerging integrase resistanceSemantic proximity Read

Dynamics of viral replication in infants with vertically acquired human immunodeficiency virus type 1 infection.Semantic proximity Read

Early antiretroviral therapy in neonates with HIV-1 infection restricts viral reservoir size and induces a distinct innate immune profile.Semantic proximity Read

Functionally competent CD4 <sup>+</sup> T cells express high levels of T-bet in <i>Plasmodium chabaudi</i> infected young miceSemantic proximity Read