Article

HSP90 inhibition disrupts telomere maintenance and promotes chromosomal instability (CIN) in cancer cells

2026-02-11

Abstract excerpt

<title>Abstract</title> <p>Background Heat shock protein 90 (HSP90) stabilizes numerous oncogenic client proteins, including factors required for telomere maintenance. Telomere dysfunction triggers chromosomal instability (CIN). To quantify telomere-directed activity and separate it from general mitotic effects, we utilized a human artificial chromosome (HAC) assay with isogenic lines carrying a linear, telomere...

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Literature Corpus work: 559b3774-c519-5904-bff2-d2baccf24d11
DOI: 10.21203/rs.3.rs-8369668/v1

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