Back to search

Article

Loss of Spindly sensitizes EML4-ALK v3 lung cancer cells to HSP90 inhibitors

2022-06-08

Abstract excerpt

Heat Shock Protein 90 inhibitors (HSP90i) have shown activity in EML4-ALK + non-small cell lung cancer (NSCLC) patients but clinical responses have been heterogeneous. It has been suggested that distinct EML4-ALK variants may have a differential impact on the response to HSP90 inhibition. Here, we show that NSCLC cells harboring the most common EML4-ALK variant 1 (v1) or variant 3 (v3) are in fact similarly sensi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
0b2e5f2a-8180-50a4-b904-6dd4584875da
DOI
10.1101/2022.06.08.495301
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 9 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Loss of Spindly sensitizes EML4-ALK v3 lung cancer cells to HSP90 inhibitorsDOI 10.1101/2022.06.08.495301
The Hsp90 inhibitor IPI-504 rapidly lowers EML4-ALK levels and induces tumor regression in ALK-driven NSCLC models.Semantic proximity
HSP90 inhibition disrupts telomere maintenance and promotes chromosomal instability (CIN) in cancer cellsSemantic proximity
EGFR inhibitor-resistant lung cancers exhibit collateral sensitivity to a covalent, cysteine-independent KEAP1 oligomerizing molecular bridge.Semantic proximity
Targeted Inhibition of the Molecular Chaperone Hsp90 Overcomes ALK Inhibitor Resistance in Non–Small Cell Lung CancerSemantic proximity
A novel C-terminal heat shock protein 90 inhibitor that overcomes STAT3-Wnt-β-catenin signaling-mediated drug resistance and adverse effectsSemantic proximity
Mitochondrial Dysfunction is a Driver for SP-2509 Drug Resistance in Ewing SarcomaSemantic proximity
The sensitivity to Hsp90 inhibitors of both normal and oncogenically transformed cells is determined by the equilibrium between cellular quiescence and activitySemantic proximity
Activity of IPI-504, a novel heat-shock protein 90 inhibitor, in patients with molecularly defined non-small-cell lung cancer.Semantic proximity
Small-molecule inhibitor of C-terminal HSP90 dimerization modulates autophagy and functions synergistically with mTOR inhibition to kill cisplatin-resistant cancer cellsSemantic proximity
Select a neighboring publication to make it the new centre.