Article
Pan-cancer analysis of copy number changes in programmed death-ligand 1 (PD-L1, CD274) - associations with gene expression, mutational load, and survival.
Genes, chromosomes & cancer - 1 Aug 2016
Budczies Jan, Bockmayr Michael, Denkert Carsten, Klauschen Frederick, Gröschel Stefan, Darb-Esfahani Silvia, Pfarr Nicole, Leichsenring Jonas, Onozato Maristela L, Lennerz Jochen K, Dietel Manfred, Fröhling Stefan, Schirmacher Peter, Iafrate A John, Weichert Wilko, Stenzinger Albrecht
Abstract excerpt
Inhibition of the PD-L1 (CD274) - PD-1 axis has emerged as a powerful cancer therapy that prevents evasion of tumor cells from the immune system. While immunohistochemical detection of PD-L1 was introduced as a predictive biomarker with variable power, much less is known about copy number alterations (CNA) affecting PD-L1 and their associations with expression levels, mutational load, and survival. To gain...
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