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Identification of transcription factors and construction of a novel miRNA regulatory network in primary osteoarthritis by integrated analysis

2 Dec 2021

Abstract excerpt

BACKGROUNDS: As osteoarthritis (OA) disease-modifying therapies are not available, novel therapeutic targets need to be discovered and prioritized. Here, we aim to identify miRNA signatures in patients to fully elucidate regulatory mechanism of OA pathogenesis and advance in basic understanding of the genetic etiology of OA. METHODS: Six participants (3 OA and 3 controls) were recruited and serum samples were...

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PMID: 34856957
DOI: 10.1186/s12891-021-04894-2

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